Investigación aplicada a la reproducción y clínica equina. (RYCE)


Un grupo de investigación dedicado al estudio de los aspectos más relevantes de la clínica y reproducción equina,   con un enfoque aplicado a la práctica de la clínica equina veterinaria para mejorar la eficiencia en la producción equina en los ámbitos de reproducción asistida, medicina y cirugía del caballo.

Investigador principal

Miembros externos

Elisa SM Da Silva (Externo-Brazil)

Líneas de investigación

1. Role of estrogens in endometrial preparation for embryo development and survival in the mare.

This research line has been on the relationship between the duration of estrus (days with dominance of estrogens and low progesterone), endometrial “receptivity” and embryo survival in the mare (from both in vivo derived and in vitro produced embryos). We have just shown that the duration of estrus influences the endometrial gene expression profile, in particular the genes known to be involved in the support of early equine embryos during the mobile phase. An increased knowledge on the physiopathology of this association surely will lead to a better understanding of the prerequisites for a “receptive endometrium” in mares and in turn to the development of veterinary strategies to increase the fertility of mares, and hence, the reproductive efficiency of horse breeding. 
2. Assisted reproduction techniques in the horse: sperm and oocytes.
This research line focuses on all aspects of assisted reproductive techniques in the mare and in the stallion, from embryo transfer, ovum pick-up and ICSI to IVF and research on in vitro sperm capacitation, to improve the general efficiency of horse breeding. 
3. Clinical applied research into equine medicine and surgery
This line of research uses clinical data from patients admitted to the Equine Hospital of University CEU Cardenal Herrera for applied research to improve the welfare  of diseased horses and advance the knowledge in the field of equine medicine and surgery.

Papel de los estrógenos en la preparación endometrial para el desarrollo embrionario en la yegua. Ref. FUSP-PPC-22-064.

Cuantía: 15.000 euros.

Duración dos años.

IP: Juan Cuervo-Arango

  1. Newcombe JR, Wilsher S, Silva ESM, Sala-Ayala L, Cuervo-Arango J. Seasonal absence of supplementary corpora lutea in pregnant mares and the relationship with pregnancy loss. J Equine Vet Sci. 2023 Nov 3;131:104960. doi: 10.1016/j.jevs.2023.104960.

  2. Martínez-Boví R, Barba M, Plaza-Dávila M, Barja I, Carbonell MD, Gerique C, Guillén-Salazar F. Effect of immunocastration with a gonadotropin-releasing hormone vaccine in a male zebra Equus quagga boehmi. Journal of Zoo and Aquarium Research 2022, 10(4).

  3. Oquendo PS, Silva ESM, Oquendo FMG, Cuervo-Arango J, Beletti ME. The effect of priming and duration of oestradiol benzoate treatment before progesterone administration on embryo development and survival in anestrous recipient mares. Reprod Domest Anim. 2022 Nov;57(11):1474-1477. doi: 10.1111/rda.14220.
  4. Velloso Álvarez A, Sandow CB, Rodgerson DH, Spirito MA. Survival and racing performance after surgical treatment of rib fractures in foals. Vet Surg. 2022 Jan;51(1):62-67. doi: 10.1111/vsu.13701
  5. Velloso Alvarez A, Boone L, Horzmann K, Hanson RR. Hybrid natural orifice transluminal endoscopy surgery (NOTES) to perform bilateral ovariectomy in mares. Vet Surg. 2022 Jul;51 Suppl 1:O174-O182. doi: 10.1111/vsu.1368
  6. Newcombe JR, Wilsher S, Cuervo-Arango J. The post-ovulatory rise in progesterone is lower and the persistence of oestrous behaviour longer during the first compared with the second cycle of the breeding season in mares. Reprod Domest Anim. 2023 Jan;58(1):141-145. doi: 10.1111/rda.14273.
  7. Martínez-Boví R, Plaza-Dávila M, Cuervo-Arango J. The effect of dexamethasone and flunixin-meglumine on ovulation, endometrial oedema, and inter-ovulatory interval length in the mare. Theriogenology. 2023 Feb;197:57-61. doi: 10.1016/j.theriogenology.2022.11.042.
  8. Umair M, Claes A, Buijtendorp M, Cuervo-Arango J, Stout TAE, Henning H. In vitro aging of stallion spermatozoa during prolonged storage at 5°C. Cytometry A. 2023 Jun;103(6):479-491. doi: 10.1002/cyto.a.24712.
  9. Silva ESM, Newcombe JR, Cuervo-Arango J. The Effect of Treatment with Oestradiol Benzoate on Oestrus Expression and Endometrial Oedema in Anovulatory and Cyclic Mares. Animals (Basel). 2023 Mar 5;13(5):938. doi: 10.3390/ani13050938.
  10. Cortez JV, Hardwicke K, Cuervo-Arango J, Grupen CG. Cloning horses by somatic cell nuclear transfer: Effects of oocyte source on development to foaling. Theriogenology. 2023 Jun;203:99-108. doi: 10.1016/j.theriogenology.2023.03.018.
  11. Newcombe JR, Cuervo-Arango J, Wilsher S. The Timing of the Maternal Recognition of Pregnancy Is Specific to Individual Mares. Animals (Basel). 2023 May 22;13(10):1718. doi: 10.3390/ani13101718.
  12. Sala-Ayala L, Martínez-Boví R, Arnal-Arnal G, Querol-Pajaanen A, Plaza-Dávila M, Cuervo-Arango J. Effect of embryo flushing technique, number of flushing attempts, and previous experience of operator on embryo recovery. J Equine Vet Sci 2023; 125:104.
  13. Velloso Alvarez A, Jose-Cunilleras E, Dorrego-Rodriguez A, Santiago-Llorente I, de la Cuesta-Torrado M, Troya-Portillo L, Rivera B, Vitale V, de Juan L, Cruz-Lopez F. Detection of equine herpesvirus-1 (EHV-1) in urine samples during outbreaks of equine herpesvirus myeloencephalopathy. Equine Vet J. 2023 Sep 12. doi: 10.1111/evj.14007.
  14. Velloso Alvarez A, Wooldridge AA, Fuller J, Shrader SM, Mansour M, Boone LH. Culture Media Supplemented With 10% Equine Serum Provided Chondroprotection in an In Vitro Co-Culture of Cartilage and Synovial Membrane. J Equine Vet Sci. 2023 Sep;128:104865. doi: 10.1016/j.jevs.2023.104865.
  15. Boorman S, Hanson RR, Velloso Alvarez A, Zhong K, Hofmeister E, Boone LH. Concurrent versus delayed exposure to corticosteroids in equine articular tissues cultured with local anesthetic. Vet Surg. 2023 Apr;52(3):361-369. doi: 10.1111/vsu.13924
  16. Busechian S, Conti MB, Sgorbini M, Conte G, Marchesi MC, Pieramati C, Zappulla F, Vitale V, Rueca F. A Comparison of the Efficacy of Two Omeprazole Formulations in the Treatment of Equine Gastric Ulcer Syndrome in Racehorses: A Blinded, Randomized Clinical Trial. J Equine Vet Sci. 2023 Jul;126:104296. doi: 10.1016/j.jevs.2023.104296.
  17. Vitale V, Laurberg M, van Galen G, van Loon G. Limitations of transthoracic echocardiography in equine patients. Vet Med Sci. 2023 Jul;9(4):1618-1620. doi: 10.1002/vms3.906.
  18. Vitale V, Nocera I, van Galen G, Sgorbini M, Conte G, Aliboni B, Verwilghen D. Breath Alcohol Test Results in Equine Veterinarians after Performing an Abdominal Ultrasound with Ethanol. Vet Sci. 2023 Mar 14;10(3):222. doi: 10.3390/vetsci10030222.