Investigación de enfermedades cardiorenales y metabólicas

1. Título del proyecto: Rotation for Optimal Targeting of Albuminuria and Treatment Evaluation. 

Investigador Principal: Hiddo J L Heerspink 

Entidad financiadora: University Medical Center Groningen 

Referencia: EudraCT Number: 2017-004641-25 (Publica) 

Duración (desde/hasta): Ongoing

Cuantía económica: N/A

2. Título del proyecto: Inmunidad adaptativa de linfocitos B y T frente a SARS-CoV-2 tras la vacunación de pacientes en riesgo de sufrir COVID-19 severa

Investigador Principal: David Navarro Ortega, Estela Giménez

Entidad financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER (Publica) 

1: Torres W, Pérez JL, Díaz MP, D'Marco L, Checa-Ros A, Carrasquero R, Angarita, L, Gómez Y, Chacín M, Ramírez P, Villasmil N, Durán-Agüero S, Cano C, Bermúdez V. The Role of Specialized Pro-Resolving Lipid Mediators in Inflammation-Induced. Carcinogenesis. Int J Mol Sci. 2023 Aug 10;24 (16):12623. doi:10.3390/ijms241612623. PMID: 37628804; PMCID: PMC10454572.

2: Navarro C, Salazar J, Díaz MP, Chacin M, Santeliz R, Vera I, D Marco L, Parra, H, Bernal MC, Castro A, Escalona D, García-Pacheco H, Bermúdez V. Intrinsic and environmental basis of aging: A narrative review. Heliyon. 2023 Jul 18;9(8):e18239. doi: 10.1016/j.heliyon.2023.e18239. PMID: 37576279; PMC10415626.

3: Checa-Ros A, Muñoz-Hoyos A, Molina-Carballo A, Viejo-Boyano I, Chacín M, Bermúdez V, D'Marco L. Low Doses of Melatonin to Improve Sleep in Children with ADHD: An Open-Label Trial. Children (Basel). 2023 Jun 28;10 (7):1121. doi:10.3390/children10071121. PMID: 37508618; PMCID: PMC10378280.

4: Viejo-Boyano I, López-Romero LC, D'Marco L, Checa-Ros A, Peris-Fernández M, Garrigós-Almerich E, Ramos-Tomás MC, Peris-Domingo A, Hernández-Jaras J. Role of the Nephrologist in Non-Kidney Solid Organ Transplant (NKSOT). Healthcare (Basel). 2023 Jun 15;11(12):1760. doi: 10.3390/healthcare11121760. PMID:37372878; PMCID: PMC10298665.

5: Bover J, Trinidad P, Jara A, Soler-Majoral J, Martín-Malo A, Torres A, Frazão J, Ureña P, Dusso A, Arana C, Graterol F, Romero-González G, Troya M, Samaniego D, D'Marco L, Valdivielso JM, Fernández E, Arenas MD, Torregrosa V, Navarro-González JF, Lloret MJ, Ballarín JA, Bosch RJ, Górriz JL, de Francisco A, Gutiérrez O, Ara J, Felsenfeld A, Canalejo A, Almadén Y. Silver jubilee: 25 years of the first demonstration of the direct effect of phosphate on the parathyroid cell. Nefrologia (Engl Ed). 2022 Nov-Dec;42 (6):645-655. doi:10.1016/j.nefroe.2023.02.008. Epub 2023 Mar 14. PMID: 36925324.

6: Ouadih-Moran M, Muñoz-Hoyos A, D'Marco L, Molina-Carballo A, Seiquer I, Checa-Ros A. Is S100B Involved in Attention-Deficit/Hyperactivity Disorder (ADHD)? Comparisons with Controls and Changes Following a Triple Therapy Containing Methylphenidate, Melatonin and ω-3 PUFAs. Nutrients. 2023 Jan 31;15(3):712. doi: 10.3390/nu15030712. PMID: 36771418; PMCID: PMC9919946.

7: Salazar J, Morillo V, Suárez MK, Castro A, Ramírez P, Rojas M, Añez R, D'Marco L, Chacín-González M, Bermúdez V. Role of Gut Microbiome in Atherosclerosis: Molecular and Therapeutic Aspects. Curr Cardiol Rev. 2023 ;19 (4): e020223213408. doi: 10.2174/1573403X19666230202164524. PMID: 36733248.

8: D'Marco L, Guerra-Torres X, Viejo I, Lopez-Romero L, Yugueros A, Bermídez V. Non-albuminuric Diabetic Kidney Disease Phenotype: Beyond Albuminuria. touchREV Endocrinol. 2022 Nov;18(2):102-105. doi: 10.17925/EE.2022.18.2.102. Epub 2022 Nov 16. PMID: 36694889; PMCID: PMC9835813.

9: D'Marco L, Checa-Ros A, Gamero D, Soto C, Salazar J, Nava M, Bermúdez V, Dapena F. Etelcalcetide and Paricalcitol in Chronic Kidney Disease: When the Target Is Inflammation. Healthcare (Basel). 2022 Dec 26;11(1):72. doi: 10.3390/healthcare11010072. PMID: 36611532; PMCID: PMC9818894.

10: Panizo N, Giménez E, Albert E, Zulaica J, Rodríguez-Moreno A, Rusu L, Giménez-Civera E, Puchades MJ, D'Marco L, Gandía-Salmerón L, Torres I, Sancho A, Gavela E, Gonzalez-Rico M, Montomoli M, Perez-Baylach CM, Bonilla B, Solano C, Alvarado MF, Torregrosa I, Gonzales-Candia B, Alcaraz MJ, Geller R, Górriz JL, Navarro D. SARS-CoV-2-Spike Antibody and T-Cell Responses Elicited by a Homologous Third mRNA COVID-19 Dose in Hemodialysis and Kidney Transplant Recipients. Microorganisms. 2022 Nov 16;10(11):2275. doi: 10.3390/microorganisms10112275. PMID: 36422345; PMCID: PMC9694477.

11: Checa-Ros A, D'Marco L. Role of Omega-3 Fatty Acids as Non-Photic Zeitgebers and Circadian Clock Synchronizers. Int J Mol Sci. 2022 Oct 12;23(20):12162. doi: 10.3390/ijms232012162. PMID: 36293015; PMCID: PMC9603208.

12: de la Espriella R, Navarro J, Mollar A, D'Marco L, Palau P, Miñana G, Llácer P, Santas E, Heredia R, González M, Górriz JL, Codina P, Díez J, Bayés-Genís A, Núñez J. Long-Term Prognostic Impact of Estimated Glomerular Filtration Rate on Admission in Patients Hospitalized for Acute Heart Failure. Cardiorenal Med. 2022;12(4):179-188. doi: 10.1159/000526105. Epub 2022 Oct 25. PMID: 36282062.

13: Montomoli M, Taco Sanchez O, D'Marco L, Gorriz Teruel JL. Impact of an article in the social age: Is tweeting the same as citing? Nefrologia (Engl Ed). 2022 Mar-Apr;42(2):125-129. doi: 10.1016/j.nefroe.2021.02.011. Epub 2022 May 11. PMID: 36153908.

14: D'Marco L, Puchades MJ, Escudero-Saiz V, Giménez-Civera E, Terradez L, Moscardó A, Carbonell-Asins JA, Pérez-Bernat E, Torregrosa I, Moncho F, Navarro J, Górriz JL. Renal Histologic Findings in Necropsies of Type 2 Diabetes Mellitus Patients. J Diabetes Res. 2022 Sep 6;2022:3893853. doi: 10.1155/2022/3893853. PMID: 36110834; PMCID: PMC9470369.

15: Panizo N, Albert E, Giménez-Civera E, Puchades MJ, D'Marco L, Gandía-Salmerón L, Giménez E, Torre I, Sancho A, Gavela E, Gonzalez-Rico M, Montomoli M, Perez-Baylach CM, Bonilla B, Solano C, Alvarado MF, Torregrosa I, Alcaraz MJ, Górriz JL, Navarro D. Dynamics of SARS-CoV-2-Spike-reactive antibody and T-cell responses in chronic kidney disease patients within 3 months after COVID-19 full vaccination. Clin Kidney J. 2022 Apr 9;15(8):1562-1573. doi: 10.1093/ckj/sfac093. PMID: 35880064; PMCID: PMC9047236.

16: Reque Santivañez J, Garcia Peris B, Panizo Gonzalez N, Perez Alba A, D'Marco L, Collado Boira E. Subclinical Hypothyroidism in Advanced Chronic Kidney Disease Patients: Prevalence and Associated Factors. J Thyroid Res. 2022 May 17;2022:1077553. doi: 10.1155/2022/1077553. PMID: 35620417; PMCID: PMC9130009.

17: Provenzano M, Puchades MJ, Garofalo C, Jongs N, D'Marco L, Andreucci M, De Nicola L, Gorriz JL, Heerspink HJL; ROTATE-3 study group; ROTATE-3 study group members. Albuminuria-Lowering Effect of Dapagliflozin, Eplerenone, and Their Combination in Patients with Chronic Kidney Disease: A Randomized Crossover Clinical Trial. J Am Soc Nephrol. 2022 Aug;33(8):1569-1580. doi: 10.1681/ASN.2022020207. Epub 2022 Apr 19. PMID: 35440501; PMCID: PMC9342643.

18: D' Marco L. Congestive Nephropathy. Int J Environ Res Public Health. 2022 Feb 22;19(5):2499. doi: 10.3390/ijerph19052499. PMID: 35270191; PMCID: PMC8909002.

19: Garcia-Llana H, Panizo N, Gandía L, Orti M, Giménez-Civera E, Forquet C, D'Marco L, Puchades MJ, Sargsyan M, Sanchís I, Ribera C, Marco MI, Ferrá CM, Pérez-Baylach CM, Bonilla B, Moncho Francés F, Perez-Bernat E, Sancho A, Górriz JL. COVID-19 Vaccination Improved Psychological Distress (Anxiety and Depression Scores) in Chronic Kidney Disease Patients: A Prospective Study. Vaccines (Basel). 2022 Feb 16;10(2):299. doi: 10.3390/vaccines10020299. PMID: 35214757; PMCID: PMC8878467.

20: D'Marco L, Puchades MJ, Gandía L, Forquet C, Giménez-Civera E, Panizo N, Reque J, Juan-García I, Bermúdez V, Gorriz JL. Finerenone: A Potential Treatment for Patients with Chronic Kidney Disease and Type 2 Diabetes Mellitus. touchREV Endocrinol. 2021 Nov;17(2):84-87. doi: 10.17925/EE.2021.17.2.84. Epub 2021 Nov 10. PMID: 35118452; PMCID: PMC8676102.

21: D'Marco L, Morillo V, Gorriz JL, Suarez MK, Nava M, Ortega Á, Parra H, Villasmil N, Rojas-Quintero J, Bermúdez V. SGLT2i and GLP-1RA in Cardiometabolic and Renal Diseases: From Glycemic Control to Adipose Tissue Inflammation and Senescence. J Diabetes Res. 2021 Nov 8;2021:9032378. doi: 10.1155/2021/9032378. PMID: 34790827; PMCID: PMC8592766.

22: Torres W, Morillo V, Manzano A, Suarez MK, Parra H, Lameda V, Nava M, D'Marco L, Puchades MJ, Medina O, Guerra-Torres XE, Bermúdez V. [Pathogenic mechanisms of SARS-CoV-2 infection and kidney disease: a clinical and molecular perspective]. An Sist Sanit Navar. 2021 Dec 27;44(3):445-456. Spanish. doi: 10.23938/ASSN.0973. PMID: 34664556.

23: Bermúdez V, Durán P, Rojas E, Díaz MP, Rivas J, Nava M, Chacín M, Cabrera de Bravo M, Carrasquero R, Ponce CC, Górriz JL, D Marco L. The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium. Front Endocrinol (Lausanne). 2021 Sep 15;12:735070. doi: 10.3389/fendo.2021.735070. PMID: 34603210; PMCID: PMC8479191.

24: Martínez MS, Manzano A, Olivar LC, Nava M, Salazar J, D'Marco L, Ortiz R, Chacín M, Guerrero-Wyss M, Cabrera de Bravo M, Cano C, Bermúdez V, Angarita L. The Role of the α Cell in the Pathogenesis of Diabetes: A World beyond the Mirror. Int J Mol Sci. 2021 Sep 1;22(17):9504. doi: 10.3390/ijms22179504. PMID: 34502413; PMCID: PMC8431704.

25: Tomás-Simó P, D'Marco L, Romero-Parra M, Tormos-Muñoz MC, Sáez G, Torregrosa I, Estañ-Capell N, Miguel A, Gorriz JL, Puchades MJ. Oxidative Stress in Non-Dialysis-Dependent Chronic Kidney Disease Patients. Int J Environ Res Public Health. 2021 Jul 23;18(15):7806. doi: 10.3390/ijerph18157806. PMID: 34360098; PMCID: PMC8345537.

26: Salazar J, Navarro C, Ortega Á, Nava M, Morillo D, Torres W, Hernández M, Cabrera M, Angarita L, Ortiz R, Chacín M, D'Marco L, Bermúdez V. Advanced Glycation End Products: New Clinical and Molecular Perspectives. Int J Environ Res Public Health. 2021 Jul 6;18(14):7236. doi: 10.3390/ijerph18147236. PMID: 34299683; PMCID: PMC8306599.

27: Montomoli M, Taco Sanchez O, D'Marco L, Gorriz Teruel JL. Impact of an article in the social age: Is tweeting the same as citing? Nefrologia (Engl Ed). 2021 Jun 29:S0211-6995(21)00108-9. English, Spanish. doi: 10.1016/j.nefro.2021.02.005. Epub ahead of print. PMID: 34215420.

28: Bermudez V, Salazar J, Martínez MS, Olivar LC, Nava M, Rojas M, Ortega Á, Añez R, Toledo A, Rojas J, Chacín M, Rodríguez JE, D'Marco L, Cano C. Age-specific waist circumference cutoff-points for abdominal obesity diagnosis: a personalized strategy for a large Venezuelan population. J Diabetes Metab Disord. 2021 Jan 16;20(1):217-227. doi: 10.1007/s40200-021-00735-0. PMID: 34178833; PMCID: PMC8212304.

29: D'Marco L, Puchades MJ, Panizo N, Romero-Parra M, Gandía L, Giménez-Civera E, Pérez-Bernat E, Gonzalez-Rico M, Gorriz JL. Cardiorenal Fat: A Cardiovascular Risk Factor With Implications in Chronic Kidney Disease. Front Med (Lausanne). 2021 May 25;8:640814. doi: 10.3389/fmed.2021.640814. PMID: 34113631; PMCID: PMC8185173.

30: Bover J, Aguilar A, Arana C, Molina P, Lloret MJ, Ochoa J, Berná G, Gutiérrez-Maza YG, Rodrigues N, D'Marco L, Górriz JL. Clinical Approach to Vascular Calcification in Patients With Non-dialysis Dependent Chronic Kidney Disease: Mineral-Bone Disorder-Related Aspects. Front Med (Lausanne). 2021 May 19;8:642718. doi: 10.3389/fmed.2021.642718. PMID: 34095165; PMCID: PMC8171667.

31: D'Marco L, Puchades MJ, Serra MÁ, Gandía L, Romero-Alcaide S, Giménez-Civera E, Molina P, Panizo N, Reque J, Gorriz JL. SARS-CoV-2 vs. Hepatitis Virus Infection Risk in the Hemodialysis Population: What Should We Expect? Int J Environ Res Public Health. 2021 May 27;18(11):5748. doi: 10.3390/ijerph18115748. PMID: 34071948; PMCID: PMC8198690.

32: Morillas C, D'Marco L, Puchades MJ, Solá-Izquierdo E, Gorriz-Zambrano C, Bermúdez V, Gorriz JL. Insulin Withdrawal in Diabetic Kidney Disease: What Are We Waiting for? Int J Environ Res Public Health. 2021 May 18;18(10):5388. doi: 10.3390/ijerph18105388. PMID: 34070103; PMCID: PMC8158374.

33: Pérez A, Torregrosa I, D'Marco L, Juan I, Terradez L, Solís MÁ, Moncho F, Carda-Batalla C, Forner MJ, Gorriz JL. IgA-Dominant Infection-Associated Glomerulonephritis Following SARS-CoV-2 Infection. Viruses. 2021 Mar 31;13(4):587. doi: 10.3390/v13040587. PMID: 33807151; PMCID: PMC8066364.

34: Gorriz JL, Arroyo D, D'Marco L, Torra R, Tomás P, Puchades MJ, Panizo N, Pantoja J, Montomoli M, Llisterri JL, Pallares-Carratalá V, Valdivielso JM. Cardiovascular risk factors and the impact on prognosis in patients with chronic kidney disease secondary to autosomal dominant polycystic kidney disease. BMC Nephrol. 2021 Mar 25;22(1):110. doi: 10.1186/s12882-021-02313-1. PMID: 33765945; PMCID: PMC7995703.

35: Gorriz JL, D'Marco L, Pastor-González A, Molina P, Gonzalez-Rico M, Puchades MJ, Sanchis I, Escudero V, Estañ N, de la Espriella R, Nuñez E, Pallardó L, Núñez J. Long-term mortality and trajectory of potassium measurements following an episode of acute severe hyperkalaemia. Nephrol Dial Transplant. 2022 Feb 25;37(3):522-530. doi: 10.1093/ndt/gfab003. PMID: 33508124; PMCID: PMC8875445.

36: Molina P, Molina MD, Pallardó LM, Torralba J, Escudero V, Álvarez L, Peris A, Sánchez-Pérez P, González-Rico M, Puchades MJ, Fernández-Nájera JE, Giménez-Civera E, D'Marco L, Carrero JJ, Górriz JL. Disorders in bone-mineral parameters and the risk of death in persons with chronic kidney disease stages 4 and 5: the PECERA study. J Nephrol. 2021 Aug;34(4):1189-1199. doi: 10.1007/s40620-020-00916-9. Epub 2021 Jan 4. PMID: 33394344.